Chloroquine method of action lysosome

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  1. Oleg_p User

    Chloroquine method of action lysosome

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    Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. The high toxicity of concanamycin A and other macrolides precludes their use in clinical therapy. The mode of action of chloroquine is as a weak lipophilic base where the free base passes easily through membranes. It accumulates in the acidic lysosome as it becomes protonated, increasing the pH of the lysosome 35,36. Following exposure to. What is the best applicable inhibitor of autophagy. chloroquine and 3-MA can inhibit autophagy at different stage. lysosomes and raises their pH, that way it inhibits autophagosome.

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    Chloroquine method of action lysosome

    Hydroxychloroquine is much less active than chloroquine., The lysosomal inhibitor, chloroquine, increases cell.

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  3. Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been used interchangeably to block autophagy in in vitro experiments assuming that they all primarily block lysosomal degradation.

    • Chloroquine inhibits autophagic flux by decreasing..
    • What is the best applicable inhibitor of autophagy?.
    • Lysosomes, pH and the Anti-malarial Action of Chloroquine.

    Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line. Mechanisms of action of chloroquine and hydroxychloroquine are thought to be the same. The mechanism that has received the most attention involves lysosomotropism, that is, the property that 4AQs accumulate within lysosomes and other intracellular acidic compartments due to protonation and sequestration of the drug 11, 14, 71, 122, 161. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.

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