Metformin and pregnancy

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    Metformin and pregnancy


    Metformin is an oral hypoglycaemic medication with a long history. First isolated in 1922, it has been available in Australasia for more than 40 years. Metformin is central to local and international guidelines for the management of type 2 diabetes and has other widening clinical indications. Apart from lowering blood glucose levels, metformin helps combat hypertriglyceridemia, has some vasoactive properties and does not cause weight gain. Metformin is usually well tolerated, however, minor side effects such as nausea and diarrhoea are relatively common. The more serious side effect of lactic acidosis is very rare. For many years, metformin was tainted by experience with a related compound, phenformin, which could cause lactic acidosis due to variations in metabolism by the liver. The early pregnancy loss rate in the metformin group was 8.8% (6 of 68 pregnancies), as compared with 41.9% (13 of 31 pregnancies) in the control group ( POLYCYSTIC OVARY SYNDROME is the most common form of female infertility in the United States, and it affects 5–10% of women of reproductive age (1, 2). Sixty-five women received metformin during pregnancy (metformin group) and 31women did not (control group). We conducted a retrospective study of all women with polycystic ovary syndrome who were seen in an academic endocrinology clinic within the past 4.5 yr and who became pregnant during that time. We hypothesized that hyperinsulinemic insulin resistance contributes to early pregnancy loss in the syndrome, and that decreasing hyperinsulinemic insulin resistance with metformin during pregnancy would reduce the rate of early pregnancy loss. In addition to poor conception rates, pregnancy loss rates are high (30–50%) during the first trimester. N.), Richmond, Virginia 23298-01113Obstetrics and Gynecology (J. N.), Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0111 Polycystic ovary syndrome is the most common form of female infertility in the United States. In addition to difficulty conceiving, women with polycystic ovary syndrome are at increased risk of miscarriage after either spontaneous or assisted conception.

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    A pregnant patient with polycystic ovary syndrome asked me whether continuing metformin, which she was taking to treat infertility before her pregnancy, was. However, the results of the few studies that have been carried out so far into the effects of taking metformin during pregnancy have been. It is anticipated that metformin use in GDM and type 2 diabetes in pregnancy will increase, especially if longer term fetal safety, or even benefit, is shown.

    Children born of mothers with polycystic ovarian syndrome who took metformin during pregnancy were more likely to have weight issues as toddlers, follow-up of two trials showed. Women randomized to metformin for gestational diabetes delivered children who weighed more (mean difference in z-score 0.38, 95% CI 0.07-0.69, There were also more 4-year-olds considered overweight or obese among those exposed to metformin in utero (32% versus 18% for placebo, OR 2.17, 95% CI 1.04-4.61), the researchers reported online in the in an email that her group "expected metformin to have a positive effect on metabolism (ameliorated hyperandrogenism and insulin resistance, and decreased weight gain in pregnancy), and thus a positive effect on the intrauterine environment and the offspring health." Moreover, a previous follow-up study had suggested a protective effect of metformin versus insulin on the metabolism of offspring born to mothers with gestational diabetes, she added. In the present study, she and colleagues followed 182 children born to mothers who were randomized to daily metformin or placebo during pregnancy in the Preg Met (Metformin in Pregnant PCOS Women) trial or its pilot study. Treatment was initiated in the first trimester of pregnancy and continued up until time of delivery. Those trials were originally designed to test whether metformin would reduce pregnancy complications, Hanem told . "Metformin passes the placenta, and the fetus is thus exposed to the drug. The follow-up was therefore conducted to investigate possible effects of intrauterine metformin exposure on the offspring health." Although metformin did not appear to have any impact on birth weight, the difference in both weight and BMI was seen in offspring as early as 6 months after delivery. ABSTRACT QUESTION A pregnant patient with polycystic ovary syndrome asked me whether continuing metformin, which she was taking to treat infertility before her pregnancy, was safe for her fetus. She had heard that metformin is a "drug for diabetes." How safe is it to take metformin during the first trimester of pregnancy and beyond? ANSWER Despite the traditional response that all oral hypoglycemic agents are absolutely contraindicated during pregnancy,1-3 evidence that metformin is probably safe during the first trimester of pregnancy and beyond is accumulating. Results of a recent meta-analysis by the Motherisk Program showed no increase in incidence of major malformations and a potential protective effect in this patient population. QUESTION Une de mes patientes enceintes ayant le syndrome des ovaires polykystiques m'a demandé s'il était sans danger pour son foetus de continuer la metformine qu'elle prenait pour traiter l'infertilité avant sa grossesse. Elle a entendu dire que la metformine était un «médicament contre le diabète». Dans quelle mesure est-ce sécuritaire de prendre de la metformine durant le premier trimestre de la grossesse et au-delà?

    Metformin and pregnancy

    Metformin exposure in first trimester of pregnancy and risk of all or., Is it safe to use metformin during pregnancy? - Medical News Today

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  4. Metformin has been shown to have encouraging effects on several metabolic aspects of polycystic ovarian syndrome, such as insulin sensitivity, plasma glucose concentration and lipid profile and since women with PCOS are more likely than healthy women to suffer from pregnancy-related problems like early pregnancy loss.

    • Effects of metformin use in pregnant patients with polycystic ovary..
    • Metformin in pregnancy – O&G Magazine.
    • Metformin in pregnancy – safe or sorry? Nature Reviews Endocrinology.

    Read what you should know about taking metformin during pregnancy if you have PCOS. It may lead to complications. Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies exploratory case-control study. BMJ 361. Mar 1, 2002. Insulin sensitivity improved for the pregnant women on metformin, compared with their sensitivity prior to pregnancy when not taking the drug.

     
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