See below for a comprehensive list of adverse effects. Applies to methotrexate: oral solution, oral tablet Other dosage forms: Oral route (Solution) Severe Toxic Reactions, Including Embryo-Fetal Toxicity Methotrexate can cause severe or fatal toxicities. Chloroquine resistant falciparum malaria drugs Reviews on plaquenil for rheumatoid arthritis Cutting plaquenil in half causing dosing errors Gluten free plaquenil The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients. Folic acid 10 mg/week is standard-prescribed to minimize MTX side effects. At start of treatment, patients are offered corticosteroid treatment, either intramuscular methylprednisolone injection 120 mg. We compare the side effects and drug effectiveness of Plaquenil and Methotrexate. The study is created by eHealthMe based on reports of 385,604 people who take Plaquenil and Methotrexate, and is updated regularly. eHealthMe has been monitoring drugs since 2008. Our original studies are referenced on 600+ peer-reviewed medical publications. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Methotrexate can cause embryo-fetal toxicity and fetal death. Monitor closely and modify dose or discontinue for the following toxicities: bone marrow suppression, infection, renal, gastrointestinal, hepatic, pulmonary, hypersensitivity and dermatologic. Methotrexate vs plaquenil side effects long term Major side effects of low-dose methotrexate - UpToDate, Plaquenil vs. Methotrexate side effect and effectiveness. Chloroquine lysosome fusionHow is hydroxychloroquine made SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Compare Plaquenil vs Methotrexate -. METHOTREXATE - ORAL side effects, medical uses, and drug.. Re Methotrexate vs Plaquenil side effects long term and short term The MTX dose for autoimmune disease is about 1/1000 the dose they use in cancer patients. MTX also has a long clinical history, which makes it a trustworthy drug, they'll be no "surprise" side effects. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Methotrexate is contraindicated in pre-existing liver conditions; making it necessary to notify your doctor of any pre-existing liver problems. Liver complications and even liver failure are possible long-term side effects of the drug.