It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Who should take plaquenil Hydroxychloroquine keratopathy Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Hydroxychloroquine has also been used as an antimalarial, but in addition is now broadly used in autoimmune diseases such as lupus and rheumatoid arthritis. Of note, chloroquine and hydroxychloroquine are considered to be safe and side-effects are generally mild and transitory. Chloroquine CQ is used to prevent and treat malaria and amebiasis,1 while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome.2 For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Hydroxychloroquine intoxication Plaquenil Side Effects Common, Severe, Long Term -, Of chloroquine and COVID-19 - ScienceDirect Plaquenil hydroxychloraquinePlaquenil maculopathy mechanismsLichen sclerosus plaquenilPlaquenil recent findings sandoz brand Mar 15, 2019 A high index of suspicion of toxicity warrants ancillary procedures to detect possible retinopathy. Based on 2016 recommendations from the American Academy of Ophthalmology, the recommended safe threshold dose has been reported as 2.3 mg/kg/d for chloroquine and 5 mg/kg/d for hydroxychloroquine. Chloroquine and Hydroxychloroquine Toxicity Treatment.. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. The Risk of Retinal Toxicity with Plaquenil. Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy. Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure. This is because hydroxychloroquine sulfate can affect the way some other medicines work. Also some medicines can affect the way hydroxychloroquine sulfate works. In particular, tell your doctor if you are taking any of the following The following medicines may increase the chance of you getting side effects when taken with hydroxychloroquine.