If blood flow to these bone cells greatly decreases, the cells may die, causing the bone to collapse. Osteonecrosis can lead to pain, arthritis and limited use of affected joints. Some people may even need joint replacement surgery. Hydroxychloroquine moa lupus Plaquenil safer than fluoroquinolones Aug 05, 2016 Background. Avascular necrosis AVN also known as osteonecrosis occur as a result of diverse etiology. Chronic inflammatory disorders, high-dose corticosteroids, excess alcohol intake, smoking, trauma, sickle cell disease, infections such as human immunodeficiency virus HIV, tuberculosis, meningococcal infections are some of the common causes AVN of bone 1, 2. Bone fractures and bone collapse due to the death of bone tissue, called avascular necrosis. Plaquenil can treat symptoms such as joint pain, mouth ulcers and skin rashes, and reduce the need. I was allergic to Plaquenil and turned redder and swelled up. Prednisone didn't help me much either. As I said on my other post I have refused Methotrexate. One thing I can tell you, I am not any meds and I have lost half of my hair. I am trying niacin for this. Blood doesn't go to our hair follicles and so the hair dies and falls out. Less often affected spots are the shoulders, hands and feet. This can result in ulcers (sores) of gum tissue, exposed jaw bone and pain. Osteonecrosis, which is also called avascular necrosis (AVN) or aseptic necrosis, is the death of bone cells due to decreased blood flow. This collapse of bone, in turn, can lead to degenerative arthritis (also called osteoarthritis) of nearby joints, most often the hips and knees. Can plaquenil cause bone avascular Plaquenil Indications, Side Effects, Warnings -, Lupus Symptoms, Causes and Treatment U. S. News Plaquenil safe during pregnancyPlaquenil screening 2018 Bone loss is found among people who take Plaquenil, especially for people who are female, 50-59 old also take medication Zometa, and have Osteoporosis. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly. Will you have Bone loss with Plaquenil - eHealthMe. PAIN Day after Methotrexate Dose - Inspire. Common and Rare Side Effects for Plaquenil Oral. Avascular necrosis AVN is a major cause of morbidity in SLE. Several factors have been associated with the development of osteonecrosis in SLE but corticosteroid therapy has been the most consistent. Many factors such as thromboembolism, fat embolism, thrombophilia, hypofibrinolysis, intramedullary haemorrhage, vasculitis and increased bone. Plaquenil and Children. Plaquenil can be dangerous to children, who are particularly sensitive to the drug. Kids shouldn't take Plaquenil as a long-term treatment. Overdose can be fatal in children. Normally, bone continuously breaks down and rebuilds—old bone is resorbed and replaced with new bone. The process keeps the skeleton strong and helps it to maintain a balance of minerals. In the course of avascular necrosis, however, the healing process is usually ineffective and the bone tissues break down faster than the body can repair them.