Chloroquine itch mouse behavior

Discussion in 'Canadian Drug' started by RVV, 12-Mar-2020.

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    Chloroquine itch mouse behavior

    This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine.

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    In each session, researchers placed a lone C57BL/6 mouse in a sound proofed cage in a quiet room and injected chloroquine disulphate diluted in phosphate buffered saline 200 μg/20 μL intradermally at the nape of the neck to induce itching. The amount of itch the mouse experiences is reflected in the frequency with which the mouse scratches itself. Chloroquine-induced itch is histamine-independent and we have reported that the nitric oxide NO/cyclic guanosine monophosphate cGMP pathway is involved in CQ-induced scratching behavior in mice. Previous studies have demonstrated that activation of N -methyl-d-aspartate receptors NMDARs induces NO production. Chloroquine, an antimalarial drug, produces severe itch by activating the histamine-independent pathway MrgprA3 receptors in mouse and MrgprX1 receptors in humans Liu et al. 2009. In the spinal dorsal horn, synaptic transmission of itch is still not fully understood Mishra and Hoon, 2015.

    Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory.

    Chloroquine itch mouse behavior

    Characterization of the chloroquine‐induced mouse model of., Peripheral NMDA Receptor/NO System Blockage Inhibits Itch.

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  4. Overexpression of pruritogens and their precursors may contribute to the sensitization of histamine-dependent and –independent itch-signaling pathways in chronic itch. We presently investigated self- and cross-sensitization of scratching behavior elicited by various pruritogens, and their effects on primary sensory neurons.

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    Chloroquine evokes histamine-independent itch in both mice and humans Green et al. 2006; Liu et al. 2009. To measure itch-related behavior induced by histamine, 2 ∼ 500 μ m histamine in 200 μl 0.4 ∼ 100 nmol was injected into the neck intradermally. After histamine injection, bouts of scratching were counted for 20 min. Blockers or inhibitors were given intraperitoneally 200 μl 30 min before the histamine challenge. Dec 24, 2009 Itch, or pruritus, is defined as the unpleasant sensation that elicits scratching behavior. In this sense, itch is quite distinct from pain, the application of which causes the hasty withdrawal of the affected body part. Nevertheless, pain and itch stimuli can sometimes interact; for instance, a pain sensation can inhibit an itch sensation.

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