Hemozoin chloroquine

Discussion in 'Canadian Drug' started by Angelina Jolie, 11-Mar-2020.

  1. Lys User

    Hemozoin chloroquine


    These hematophagous organisms such as Malaria parasites (Plasmodium spp.), Rhodnius and Schistosoma digest haemoglobin and release high quantities of free heme, which is the non-protein component of hemoglobin. Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring.

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    Hemozoin is involved in several aspects of the pathology of the disease as well as in important processes such as the immunogenicity elicited. It is known that the once best antimalarial drug, chloroquine, exerted its effect through interference with the process of hemozoin formation. In malaria parasites, hemozoin is often called malaria pigment. Since the formation of hemozoin is essential to the survival of these parasites, it is an attractive target for developing drugs and is much-studied in Plasmodium as a way to find drugs to treat malaria malaria's Achilles' heel. The ability of chloroquine to inhibit hemozoin formation suggests that this and related compounds may be interfering with the heme-detoxification process, making the parasites susceptible to oxidative stress by heme. 187,188 The exact molecular details of this interference have been the subject of much discussion, and studies over the last several years tend to show that inhibition of hemozoin formation may either be due to the direct complexation of quinolines with hematin.

    In malaria parasites, hemozoin is often called malaria pigment. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin.

    Hemozoin chloroquine

    Chloroquine - Wikipedia, Hemozoin - Wikipedia

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  7. SCOPE OF REVIEW Hemozoin is involved in several aspects of the pathology of the disease as well as in important processes such as the immunogenicity elicited. It is known that the once best antimalarial drug, chloroquine, exerted its effect through interference with the process of hemozoin formation.

    • Malarial hemozoin from target to tool. Semantic Scholar.
    • Chloroquine - an overview ScienceDirect Topics.
    • Mechanisms of drug action and resistance.

    The mutants produce little or no hemozoin Hz, the detoxification by-product of Hb degradation. Further, they are resistant to chloroquine, an antimalarial drug that interferes with Hz formation, but their sensitivity to artesunate, also thought to be dependent on Hb degradation, is retained. Chloroquine forms a drug-hemozoin complex, and this complex caps the polymerizing chain, thereby preventing additional polymerization. Along with the prevention of polymerization, the free heme accumulates in the food vacuole, exerting its toxic effects on the parasite. Chloroquine also functions as an anti-autoimmune therapy. Chloroquine does not prevent relapses in patients with vivax or malariae malaria because it is not effective against exoerythrocytic e.g. liver forms of the parasite, nor will it prevent vivax or malariae infection when administered as a prophylactic

     
  8. BULLDOG Well-Known Member

    In some cases, they may not be available in every strength or form as the brand-name drug. Plaquenil Warnings and Precautions - Antibiotics Home Page Taking Plaquenil for Rheumatoid Arthritis PLAQUENIL Warnings Pregnancy & Lactation RxSaver by.
     
  9. scards User

    The study is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Hypotension (abnormally low blood pressure) has been reported by people with high blood pressure, rheumatoid arthritis, pain, multiple sclerosis, primary pulmonary hypertension. Can plaquenil cause low blood pressure? - Low Blood Pressure - When Blood Pressure Is Too Low. Will you have High blood pressure with Plaquenil - eHealthMe
     
  10. nightbloos Moderator

    Hydroxychloroquine Side Effects - Sep 13, 2019 Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Incidence not known Blistering, peeling, loosening of the skin

    Chloroquine Side Effects -