Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil and anthrax vaccine Chloroquine is ineffective on the exoeryhto Metformin versus hydroxychloroquin for tyle 2 diabetes Jeanneac - I would be willing to bet it is the prednisone, not the plaquenil, that is contributing to your insomnia. Almost everyone on prednisone has some issues with sleeping -- it is very often accompanied by some sort of sleeping aid. Some of us are ok with an OTC sleep medication, some need a prescript ion. It is probably one of those things that is related to our individual reactions to medications. The other thought is that Plaquenil has an anti-inflammatory effect and when one feels some better our energy levels rise. One can only hope that is how the rest of us will feel. I have been on the Plaquenil since last September and take it after lunch. Generally not feeling well but have an over excess of energy. Trouble concentrating on tasks. Chest congestion, difficulty sleeping Plaquenil worked wonders on my pain, but the side effec. ” Druginformer Identified Side Effects Tremor, Arthralgia, Chest pain, Nausea. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil related to insomnia Anxiety and Plaquenil Has anyone experienced mood. - LUPUS UK, Plaquenil and Sleep - Sjogren's World Hydroxychloroquine swollen lymph nodesPlaquenil and sleepiness Plaquenil seems to have a good reputation, I researched it after my new rheumy prescribed it even before he wrote lupus as a diagnosis. He said it is preventitive for down the road and prudent to give it even before lupus has been ruled in. Plaquenil questions. -. Hydroxychloroquine Sulfate Insomnia Reports - DrugInformer. Hydroxychloroquine Plaquenil. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Plaquenil isn't known for causing insomnia. It is also a drug that stays in your system for a long time and takes a long time getting IN to your system. It takes 3-5 months to work and just as long to get out of your system. Summary Insomnia is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA.