Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Chloroquine osteoarthritis Benefits of plaquenil and rheumatoid arthritis Chloroquine and quinine are commonly used to treat Taking plaquenil with imuran The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Oral pigmentation is a relatively common condition that may involve any portion of the oral cavity. Multiple causes are known, and they may range from simple iatrogenic mechanisms, such as implantation of dental amalgam, to complex medical disorders, such as Peutz-Jeghers syndrome. Nov 01, 2019 Oral pigmentation is a relatively common condition that may involve any portion of the oral cavity. Multiple causes are known, and they may range from simple iatrogenic mechanisms, such as implantation of dental amalgam, to complex medical disorders, such as Peutz-Jeghers syndrome. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Chloroquine pigmentation Chloroquine Side Effects Common, Severe, Long Term -, Disorders of Oral Pigmentation Background. Icd 10 code for long term use of plaquenilPlaquenil for arthritis side effectsChloroquine ocular side effectsWhat can plaquenil due to help ra or lupusLupuslike illness normal bloodwork plaquenil effective The pigmentation resolved in two patients following chloroquine withdrawal despite being substituted by hydroxychloroquine. Hence, hydroxychloroquine may score over chloroquine not only with reference to ocular toxicity 9, but also with reference to cutaneous toxic-ity, for its long term use in patients suffering from con- Hyperpigmentation of the Skin Following Chloroquine.. Disorders of Oral Pigmentation Background, Pathophysiology.. Antimalarial Induced Skin Pigmentation. Thank you for your interest in spreading the word about The BMJ. NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. Mucocutaneous hyperpigmentation because of anti-malarial therapy has been reported since World War II 2; however, HCQ-associated hyperpigmentation seems to be less common than with other antimalarials such as chloroquine 3,4onset of HCQ-associated hyperpigmentation ranges from 3 months to 22 years following the initiation of therapy, with a median of 6.1 years 1. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action.