Chloroquine heme polymerase

Discussion in 'Canadian Pharcharmy' started by TECH-KREP, 28-Feb-2020.

  1. McPro XenForo Moderator

    Chloroquine heme polymerase


    These hematophagous organisms such as Malaria parasites (Plasmodium spp.), Rhodnius and Schistosoma digest haemoglobin and release high quantities of free heme, which is the non-protein component of hemoglobin. Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring.

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    It has high affinity for chloroquine, which is another mechanism for trapping chloroquine. Once trapped, chloroquine acts by one of many ways a. Inactivation of heme-polymerase responsible for conversion of heme part of hemoglobin into hemozoin. Conversion does not take place, heme is toxic to plasmodium, resulting in death of plasmodium. b. When treated with chloroquine, the enzyme heme polymerase is inhibited, leading to the heme-induced demise of non–chloroquine-resistant merozoites. A mature schizont within an erythrocyte. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids.

    In malaria parasites, hemozoin is often called malaria pigment. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin.

    Chloroquine heme polymerase

    Chloroquine - an overview ScienceDirect Topics, What is the role of hemozoin in the etiology of malaria?

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  6. Chloroquine A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

    • Definition of chloroquine - NCI Drug Dictionary - National..
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    Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. New data are also presented which show that heme polymerase isolated from chloroquine resistant trophozoites retains full sensitivity to drug inhibition, consistent with the observation that resistance involves a reduced accumulation of the drug at the still vulnerable target site.

     
  7. Want2mooN XenForo Moderator

    For destinations (see the next section in this chapter, Malaria Risk Information and Prophylaxis, by Country) where malaria cases occur sporadically and risk for infection to travelers is assessed as being very low, it is recommended that travelers use mosquito avoidance measures only, and no chemoprophylaxis should be prescribed. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center Taking Plaquenil for Various Conditions and Treatment Tips
     
  8. Banderas Guest

    The following information is NOT intended to endorse any particular medication. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil Hydroxychloroquine for Lupus - LupusCorner What are your thoughts on Benlysta? - Lupus - Inspire
     
  9. maddy User

    Recommendations on Screening for Chloroquine and. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools.

    New Plaquenil Guidelines -