Advice should be individually optimized to achieve a high degree of protection and compliance. Individual risk assessment takes into consideration the duration of stay in the endemic area, the individual exposure, the seasonal transmission rates, and the drug-resistance situation. Coming off plaquenil Maqular degeneration plaquenil This occurs with long-term use over many years or with high doses. Patients on long-term chloroquine therapy should be screened at baseline and then annually after five years of use. The daily safe maximum doses for eye toxicity can be computed from one's height and weight using what the cited source describes as "this calculator". Applies to chloroquine compounding powder, injectable solution, oral tablet. Ocular. Maculopathy and macular degeneration may be irreversible. Irreversible retinal damage has been reported in patients receiving long-term or high-dose 4-aminoquinoline therapy. Retinopathy has been reported as dose related. Before using chloroquine for prophylaxis, it should be ascertained whether chloroquine is appropriate for use in the region to be visited by the traveler. Chloroquine should not be used for treatment of infections acquired in areas of chloroquine resistance or malaria occurring in patients where Chloroquine prophylaxis has failed. P. falciparum Exposure-prevention methods may be combined with standby treatment in lower transmission areas if the traveler has been trained to take the antimalarials appropriately. Methods for prevention of exposure may help reduce the reliance on chemoprophylactic drugs. Long term chloroquine prophylaxis Long-Term Malaria Prophylaxis for Travelers, Chloroquine Side Effects Common, Severe, Long Term - Show me a picture of plaquenilChloroquine chikungunyaHydroxychloroquine 200 mg tab costHydroxychloroquine plaquenil for malaria protection peru These patients are also at risk of developing chloroquine retinopathy. Irreversible visual impairment resulting from accumulation of chloroquine in the retina is a recognized complication of long-term, high-dosage therapy. Total lifetime exposure to chloroquine should not exceed 100g of the base. WHO Model Prescribing Information Drugs Used in Parasitic.. CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG. Long-term prophylaxis with weekly mefloquine. Taking chloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking this medicine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Chloroquine appears to be more retinotoxic than hydroxychloroquine. Screening recommendations for chloroquine All patients planning to be on long-term treatment should receive a baseline examination including fundus photography and spectral domain optical coherence tomography within 6-12 months of treatment initiation; Long term use of chloroquine can affect the eyes, leading to patchy vision. Eye examinations and blood tests may be necessary for those on very long term chloroquine. Those with kidney or liver disease should be assessed carefully before taking this medication.