Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. How commonly is hydroxychloroquine used for autoimmune Chloroquine cellular toxicity Protocolled treatment of RA patients at both clinics consisted of MTX 25 mg/week reaching maximum dose within 4–8 weeks, preferably subcutaneously, and HCQ 400 mg/day as soon as feasible after diagnosis. Folic acid 10 mg/week is standard-prescribed to minimize MTX side effects. Hi JJinIN- I am recently diagnosed with lupus. My rheumatologist prescribed plaquenil, neurontin, prednisone, methotrexate, folic acid, and reglan. I take 7.5mg of the methotrexate weekly and I started three weeks ago. I have had no problems at all with nausea, diarrhea, or any other symptoms. The good news These common side effects can often be short-circuited by taking a folic acid supplement. Folic acid is the synthetic form of folate. One study found that rheumatoid arthritis RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Methotrexate. A medication for Lupus, Any one using Methotrexate?" Lupus Community - Support Group Hydroxychloroquine glucose levelsCheap aralen dosageDeae dextran chloroquine methodChloroquine calcium phosphate transfection Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate vs Plaquenil Comparison -. Methotrexate Managing Side Effects Arthritis Foundation. Immune & Autoimmune - Lupus methotrexate and leucovorin. A weekly dose of methotrexate can cause unpleasant side effects, so Dooley recommends taking it when you have a couple of days off. For example, on Fridays, if you work during the week. “If you don’t feel 100 percent afterward, you have the weekend to get through it,” she says. It’s also important to avoid alcohol while taking methotrexate. Some patients complain of headache, fatigue, and feeling “wiped out” also called methotrexate “fog”. These side effects can often be overcome by increasing folic acid or using an activated form of folic acid known as folinic acid leukovorin® given as a 5mg dose 12 hours and sometimes 24 hours after methotrexate is given. Folic acid may also help with many of the other common side effects from methotrexate, such as fatigue, headaches, hair loss, and oral ulcers. Ask your doctor if folic acid might help you -- don't.