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  8. ViktorSot Well-Known Member

    Atenolol and metoprolol tartrate are commonly prescribed β-blockers. Atenolol elimination depends on kidney function, whereas metoprolol tartrate does not. We hypothesized that compared to metoprolol tartrate, initiating oral atenolol treatment would be associated with more adverse events in older adults, with the association most pronounced in patients with lower baseline estimated glomerular filtration rates (e GFRs). Older adults (mean age, 75 years) in Ontario, Canada, prescribed oral atenolol versus metoprolol tartrate from April 2002 through December 2011. The 2 groups were well matched (n = 75,257 in each group), with no difference in 31 measured baseline characteristics. Patients with end-stage renal disease were ineligible, and 4.6% of patients had chronic kidney disease (median e GFR, 38 m L/min/1.73 m Compared to metoprolol tartrate, initiating atenolol treatment was not associated with higher risk of hospitalization with bradycardia or hypotension (incidence, 0.71% vs 0.79%; relative risk, 0.90; 95% CI, 0.80-1.01). Atenolol treatment initiation was associated with lower 90-day risk of mortality than metoprolol tartrate (incidence, 0.97% vs 1.44%; relative risk, 0.68; 95% CI, 0.61-0.74). Effects of beta blockers atenolol or metoprolol on heart rate variability. Kidney Function and Population-Based Outcomes of Initiating Oral. Perioperative β-BlockadeAtenolol Is Associated with Reduced.
     
  9. -dmitriy- New Member

    In addition to an ABC News producer’s 7-month-old son who has developed the skin form of anthrax after visiting his mother’s workplace, other children may also have been exposed to lethal spores at another media outlet — American Media Inc. Employees of the supermarket-tabloid publishing company were encouraged to bring their kids to the office with them, since many of the chain’s reporters, editors and photographers worked long hours. “Cipro hasn’t traditionally been given to kids under 21,” said Dr. Doctors have prescribed AMI’s more than 300 employees there Ciprofloxacin, the drug of choice to combat anthrax, as a prophylactic in case they’ve been exposed to the disease. George Miceli, chief of emergency medicine at Boca Raton Community Hospital, which has tested and treated AMI employees exposed to anthrax. The Food and Drug Administration and Centers for Disease Control and Prevention “only recently recommended it” as a first line of defense against anthrax for kids, as well as adults, he said. Cipro, as a broad-spectrum antibiotic which can kill a lot of bugs, can cause liver damage, severe diarrhea and even miscarriages. FDA guidelines for treating anthrax with Cipro call for patients to take one 500-mg tablet or liquid suspension twice a day for 60 days. The unusually long period of treatment is due to anthrax spores’ ability to survive up to two months. With that in mind, pediatricians are prescribing a milder antibiotic — amoxicillin — as an alternative, albeit effective, drug for kids exposed to anthrax, Miceli said. In fact, there’s been a run on the drug at pharmacies in the Boca Raton area since the anthrax outbreak there, he says, although no children there have tested positive for anthrax. Cipro Pediatric Dosing - Epocrates Online Fluoroquinolones in children - World Health Organization AAP report details use of fluoroquinolones in children
     
  10. kudya Guest

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