Chloroquine and receptor mediated endocytosis

Discussion in 'Chloroquine Online' started by lpu, 05-Mar-2020.

  1. AleZver New Member

    Chloroquine and receptor mediated endocytosis


    Detailed information on how Wiley uses cookies can be found in our Privacy Policy. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it.

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    The third and the most specific mechanism of endocytosis is receptor-mediated endocytosis. During receptor-mediated endocytosis, receptors in the plasma membrane identify the macromolecules like cholesterol in the extracellular fluid. However, the main difference between endocytosis and phagocytosis is their correlation of the mechanisms. This paper investigates whether the increased toxicity of Tf-RIPs induced by monensin and chloroquine may be due to alterations of the normal endocytotic pathway of the complexes mediated by the transferrin receptor. Jun 01, 2009 As clathrin-dependent endocytosis is known to be involved in TGFβ-induced signaling, we wished to determine the effects of known inhibitors of clathrin-dependent endocytosis on internalization of cell-surface-bound TGFβ in Mv1Lu cells.

    It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance.

    Chloroquine and receptor mediated endocytosis

    Receptor-mediated endocytosis - Wikipedia, The effect of monensin and chloroquine on the endocytosis.

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    • PDF Effects of chloroquine on lysosomes and endocytosis..
    • Inhibitors of clathrin-dependent endocytosis enhance TGFβ..
    • Chloroquine and ammonium ion inhibit receptor-mediated..

    In receptor-mediated endocytosis, as in phagocytosis, clathrin is attached to the cytoplasmic side of the plasma membrane. If uptake of a compound is dependent on receptor-mediated endocytosis and the process is ineffective, the material will not be removed from the tissue fluids or blood. Inhibition of viral infection mediated by chloroquine can occur in both the early and later stages of the viral replication cycle 30,31. To evaluate which step of the viral cycle was susceptible to inhibition, chloroquine was added to Vero cells at different time points post-infection with ZIKV MR766. Required for receptor-mediated endocytosis of IL-2, 1F1gcWT cells were treated with 125I-labeled IL-2 in the cold, and inter-nalization of the surface-associated IL-2 was initiated by cul-turing the cells at 37 °C in the absence or presence of the proteasome inhibitor MG132 Fig. 1. During the first 10–15

     
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