The mainstay of treatment for malaria is chloroquine

Discussion in 'Chloroquine Phosphate 500 Mg' started by PJ`, 04-Mar-2020.

  1. KinoshnikZ User

    The mainstay of treatment for malaria is chloroquine


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria. Chloroquine is cheap and has been on the market for many years. It therefore may potentially be a good treatment option until a vaccine against the coronavirus is available. Chloroquine has been marketed internationally since 1934 as an antimalarial treatment. Chloroquine can be used to kill malaria parasites living in red blood cells but the medication may not necessarily be efficient at killing these parasites in other body tissues. Doctors often prescribe this medication as part of certain treatment plans for lupus and other immune system diseases.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    The mainstay of treatment for malaria is chloroquine

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Malaria drug chloroquine potential treatment for coronavirus

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  3. Chloroquine is not embryo- and fetotoxic when used at the usual dose for malaria prophylaxis or for a three-day treatment of a typical malaria attack McGready 2002, Phillips-Howard 1996. Current evidence does not suggest fetal ocular toxicity when chloroquine was used as antimalarian medication during pregnancy review by Osadchy 2011.

    • Chloroquine - an overview ScienceDirect Topics.
    • What Is the Difference between Hydroxychloroquine and..
    • Chloroquine Resistance in Malaria - ResearchGate.

    Summary. Aralen is the brand name for the generic drug chloroquine, an anti-malaria drug used to treat malaria and amebiasis infection that's spread outside of the intestines. Dosage, drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this drug. Chloroquine CQ has remained the first-line of treatment for P. vivax since the 1940s 2 and seemed to be universally effective until the first case of CQ-resistant P. vivax was reported from Papua New Guinea 3. There have been some reports of CQ resistance across the globe 4 but CQ remains the mainstay of treatment in most regions. Resistance to anti-malarials is a major challenge for effective malaria control in sub-Saharan Africa. This triggered a need for routine monitoring of the efficacy of the antimalarial drugs every two years in all malaria endemic countries. Chloroquine remained the drug of choice for the treatment of vivax malaria in Ethiopia.

     
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