Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. The mainstay of treatment for malaria is chloroquine Chloroquine keratopathy Chloroquine 250 mg tablet Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. Check the latest outcomes from 53,829 Plaquenil users, or browse all drugs. What is Inflammation? Inflammation has been reported by people with rheumatoid arthritis, high blood pressure, pain, osteoporosis, crohn's disease. According to the Mayo Clinic, the daily dose for RA is based on body weight; the dose is 2.9mg per pound 1. This means many people taking Plaquenil for RA are taking a dose of 400mg a day or higher. Pigment deposits in the retina can cause vision changes, according to Steven Ofner, M. D. of Eugene Oregon Eye Care. The typical dose for hydroxychloroquine is 200-400mg per day and is based on a person’s body weight or if you are overweight, your ideal body weight. While hydroxychloroquine is considered a relatively safe medication, like all medications there are potential risks. These include body rashes that often will itch. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. What does plaquenil do to the body Protecting your eyesight when taking Plaquenil Lupus Foundation of., Long-Term Side Effects of Plaquenil for Rheumatoid. Risk of plaquenil toxicityWhat is a plaquenil eye exam Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time may harm the retina, causing serious vision loss. People with retinal damage from Plaquenil are not aware at first that they are losing vision. What Is Plaquenil? - American Academy of Ophthalmology. Ask the Expert Plaquenil and Sjögren’s. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. For people who weigh less than 80 kg, a lower daily dose is prescribed, up to a maximum of 5 mg/kg of body weight. Other risk factors for Hydroxychloroquine retinal toxicity include kidney or liver disease and obesity. Obesity is a risk factor because the drug does not penetrate fat tissue so there is more of the drug in your lean body mass including your retina and its supporting cells called the retinal pigment epithelium. From what I understand it is very rare for someone to have an allergic reaction to the Plaquenil and when they do that isn't how it shows up. Hopefull it's not the Plaquenil because this drug is really a very good drug for Lupus. I went through some paperwork I had about Plaquenil and am pasting it here for you to read.