This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Dextromethorphan is a noncompetitive N-methyl D-aspartate receptor antagonist that is clinically feasible for relieving the opioid withdrawal symptoms. This study compares the efficacy of a combination therapy with dextromethorphan and clonidine to treatment with clonidine alone. In this double-blind randomized clinical trial, patients were selected from inpatients of detox and rehabilitation ward of Razi Hospital, Tabriz, Iran. They were randomly allocated to two groups receiving either clonidine (0.4–1.2 mg/day) or clonidine and dextromethorphan (300 mg/day). Withdrawal symptoms were evaluated in the first day of admission and again 24, 48, and 72 hours later. Thirty male patients completed the trial in each group. Withdrawal symptoms began to decrease in the second day in patients receiving dextromethorphan and clonidine while patients receiving clonidine experienced the more severe symptoms in 72 hours. Analysis of variance of the symptom severity score revealed a significant group ), so that patients receiving dextromethorphan plus clonidine had milder symptoms during three days in all of the measurements compared to clonidine group. Combination therapy of dextromethorphan and clonidine would result in milder opioid withdrawal symptoms compared to clonidine alone with a reduction beginning at the second day. Addiction is one of the most disturbing and problematic social phenomena in current years with known social, economic, and individual detriments. Infants exposed to opioids in utero and postnatally are at risk for developing withdrawal symptoms upon discontinuation of the drugs. This condition is known as the neonatal abstinence syndrome (NAS). Different medications have been used to ameliorate the symptoms of withdrawal, most commonly opioids. Clonidine has also been evaluated both as an additive and alternative option for the treatment of opioid withdrawal symptoms. Data evaluating the use of clonidine for the treatment of NAS are limited; only six studies have been published. The α-2 adrenergic receptor agonist clonidine is believed to reduce the excessive noradrenergic activity that results from opioid withdrawal. Clonidine has the potential to serve as an attractive option to treat NAS because it possesses a favorable adverse effect profile, is easy to administer, and does not require a long tapering period, unlike other agents currently used to treat NAS. Prednisone west ward 473 Fluconazole prescribing information Prozac 30mg Different medications have been used to ameliorate the symptoms of withdrawal, most commonly opioids. Clonidine has also been evaluated both as an. Jun 11, 2013. Withdrawal symptoms were evaluated in the first day of admission and. Clonidine is being used in the treatment of withdrawal syndrome. Clonidine therapy for narcotic withdrawal. Kleber HD. Opiate withdrawal using clonidine. A safe. Clonidine blocks acute opiate-withdrawal symptoms. Combining prescription medications with alcohol can have serious side effects. This is especially the case if the drug used and alcohol have similar effects. One example of a medication abused along with alcohol is clonidine. Clonidine isn’t a scheduled substance because it’s primary purpose is to treat hypertension, and it’s not abused as frequently as opioids and benzodiazepine tranquilizers. Besides hypertension, clonidine – also known by the brand name Catapres – is used to treat anxiety disorders, pain disorders, panic attacks, and attention deficit hyperactivity disorder. It’s available in 0.1 mg, 0.2 mg, and 0.3 mg dosages. The drug classifies as a centrally acting alpha-agonist. Unmanaged opiate withdrawal can be a significant obstacle to receiving treatment for and recovering from opiate addiction. Opiate withdrawal refers to the symptoms and side effects that occur when someone stops using opiates To begin inpatient or outpatient substance abuse treatment, a person must first go through opiate detox. Once all the drugs are removed from a person’s system, that person can begin treatment. During a medical detox, there are certain prescription and over-the-counter medications that can be provided. These medications achieve three primary goals Catapres is a brand-name prescription medication. While it is often referred to by the generic name clonidine, it is also available under the brand name Kapvay. The FDA approves the medication for the treatment of high blood pressure. Clonidine used for withdrawal symptoms Using Clonidine for Opiate Withdrawal - River Oaks, The Therapeutic Effect of Adding Dextromethorphan to Clonidine for. Prednisone deltasone side effectsFluconazole once a weekCialis how fastCipro is poison Jul 23, 2014. Clonidine Catapres is used for treating high blood pressure. you stop using clonidine, or using the drug to avoid withdrawal symptoms. Clonidine Catapres - Side Effects, Dosage, Interactions - Drugs. Clonidine therapy for narcotic withdrawal.. How Clonidine Can Manage Withdrawal Symptoms - Desert Hope. This medication is often used in drug treatment, especially for opioids like heroin. It may be given to help with the symptoms of withdrawal which can be so severe. Besides hypertension, clonidine – also known by the brand name Catapres. it won't reduce cravings, clonidine can treat the symptoms of opiate withdrawal. Clonidine is primarily used to treat high blood pressure. In this post, we will review common clonidine withdrawal symptoms.