Tamoxifen brain fog

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  1. technick Well-Known Member

    Tamoxifen brain fog


    Mamakct wrote: I have been taking Tamoxifen for 3 years, and I just heard a connection to brain fog. I'm definitely suffering from brain fog--inability to retain information, confusion, feeling scattered. I had attributed it to the trauma of diagnosis and a couple of simultaneous life changes--or to peri-menopause, but I'm wondering if there is something to this. If you have experienced, I would be curious if it lifts after the 5 year Rx, and I would also be interested in some self-care recommendations to help. I did feel it lift when I went to Kripalu for a few days--no tv, daily yoga, limited electronics, super-healthy food, no news. I'm considering drastically reducing or eliminating TV and internet. My coach recommended weekly detox baths of epsom salts and baking soda. Nov 19, 2016 PM Li LBit1067 wrote: Hi mamkct, I have been taking Tamoxifen for a year now. I too have the brain fog, inability to retain information, and thinking of everyday words when talking with someone. I have blamed most of this on menopause....I started taking Tamoxifen, I was thrown right into menopause. Maybe it's the combination of both Tamoxifin and menopause that gives me foggy brain?? One of the most common side effects mentioned was “brain fog” – memory loss and concentration issues brought on by use of tamoxifen or aromatase inhibitors. With recent studies and oncologists like Dr Munster telling us that ten years on those drugs carry greater survival benefits than five, combatting side effects seems more important than ever. Dr David Porter, at Auckland Hospital, is one of the principal investigators on the Mag Lev trial, which is looking at using magnesium to mitigate those memory and concentration issues. Over his career many patients have come to him with cognitive side effects. “It’s quite a significant issue for women,” he says, “and we know that when women come off hormone therapy their cognition improves.” Porter believes this problem doesn’t start in the brain, but in the kidneys. Recent studies have shown that when estrogen is blocked or depleted, as it is during hormone therapy, magnesium is lost from the kidneys. That’s led him to believe that low magnesium levels in the body can lead to memory and concentration issues; people with Alzheimer’s disease tend to have low levels of magnesium too.

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    The researchers were able to isolate the cells in the human brain. "There is a subset of women who report this mental fog while on tamoxifen. Sep 5, 2017. The side effects of tamoxifen use include vasomotor and gynecologic symptoms, such as hot flashes, night sweats, and vaginal dryness, and. So I'm on week nine of taking Tamoxifen and having some serious. Im on tamoxifen and also have brain fog headaches,body aches,hot.

    A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to “chemo brain.”However, in the Journal of Neuroscience, researchers also report they’ve discovered an existing drug compound that appears to counteract or rescue brain cells from the adverse effects of the breast cancer drug. D., professor of Biomedical Genetics and director of the UR Stem Cell and Regenerative Medicine Institute, said it’s exciting to potentially be able to prevent a toxic reaction to one of the oldest and most widely used breast cancer medications on the market. Although tamoxifen is more easily tolerated compared to most cancer treatments, it nonetheless produces troubling side effects in a subset of the large number of people who take it. By studying tamoxifen’s impact on central nervous system cell populations and then screening a library of 1,040 compounds already in clinical use or clinical trials, his team identified a substance known as AZD6244, and showed that it essentially eliminated tamoxifen-induced killing of brain cells in mice.“As far as I know, no one else has discovered an agent that singles out and protects brain and central nervous system cells while also not protecting cancer cells,” said Noble, who also collaborates with researchers at the UR's James P. “This creates a whole new paradigm; it’s where we need to go.”The research is the result of two separate but related projects from Noble’s lab. One investigates the science underlying a condition known as “chemo brain,” and another is looking at how to exploit tamoxifen’s attributes for use in other types of cancer besides early-stage, less-aggressive breast cancer. (The drug is a type of hormonal therapy, which works by stopping the growth of estrogen-sensitive tumors.)In the Journal of Neuroscience paper, Noble’s team first identified central nervous system (CNS) cells that are most vulnerable to tamoxifen toxicity. Chief among these were oligodendrocyte-type 2 astrocyte progenitor cells (O-2A/OPCs), cells that are essential for making the insulating sheaths (called myelin) required for nerve cells to work properly. Exposure to clinically relevant levels of tamoxifen for 48 hours killed more than 75 percent of these cells. Hi am on tamoxifen now nearly 5 months and side effects getting worse . I really thought I was losing it, forgetting simple things , even every day words could not think what items were called. Repeating full sentences 10 min later forgetting I had just said the exact thing. Along with terrible joint pain and hot flushes every 1 1/2 hours during the night. Went for first check up today and yes memory fog is a side effect in 1%. They now decided to get me to stop the tamoxifen or 3 weeks to clear my system and see if any or all side effects go. Then start back on half a tablet for 2months then the full tablet. Also only a few still have boob pain after lumpectomy and guess again who the lucky girl is. Also did you know in order to get eyes lasered you have to be on tamoxifen for a year and finished rads for 6 months. Hi Gtl Heart, I was told that my ongoing breast pain and swelling after lumpectomy is due to the radiotherapy and that it could take up to 2 years to recover. They did a mammogram also and it seemed fine, but the pain ,because boob still tender was unreal. Once I got over the initial sunburnt look post radiation, the swelling lessened but then flared up 6 afterwards and has stayed like that since. I have a foggy brain too but I think it's from chemo.

    Tamoxifen brain fog

    Tips for Managing Chemobrain - Dana-Farber Cancer Institute., Nationwide Case-Control Study Examining the Association between.

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  3. Dec 20, 2018. It came down to quality of life, and I had none on the tamoxifen. genuinely feel like a different person - debilitating fatigue, brain 'fog', anxiety.

    • Coming off tamoxifen - Breast Cancer Care Forum - 334892.
    • Tamoxifen, Bone aches, brain fog and poor memory. Any one else..
    • Tips on Tamoxifen Side Effects - Brain Fog AnswersBeyond5 Blog.

    While tamoxifen acts like an anti-estrogen in breast cells, it acts like an. shortness of breath, or chest pain, because these can be symptoms of a DVT or PE. Mental Fog with Tamoxifen is Real; Scientists Find Possible Antidote. the breast cancer drug tamoxifen is toxic to cells of the brain and central. Dec 6, 2012. THURSDAY, Dec. 6, 2012 — Women who take the breast cancer drug Tamoxifen for a longer period of time could further reduce their chances.

     
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