Before applying this medicine, thoroughly wash the affected area with warm water and soap, rinse well, and pat dry. After washing or shaving, it is best to wait 30 minutes before applying the pledget (swab), topical gel, or topical liquid form. The alcohol in them may irritate freshly washed or shaved skin. However, to help keep your acne under control, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. You may have to continue using this medicine every day for months or even longer in some cases. If you stop using this medicine too soon, your symptoms may return. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Erythromycin 2% Topical Solution (60 ml Bottle) Erythromycin 2% Topical Solution (60 ml Bottle) Customer Service. 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Check out the browser extension in the Firefox Add-ons Store. Erythromycin is a topical antibiotic that is used to treat inflammatory acne. It comes in many different forms, from lotions, gels, and ointments, to toner-like solutions and pledgets (small pads soaked in the medicated solution, similar to a Stridex pad). Topical erythromycin only targets one acne-causing factor: bacteria. There are other factors that are responsible for acne breakouts, like the abnormal shedding of skin cells and the development of pore blockages, that topical erythromycin just doesn't address. More importantly, a big issue with topical antibiotics and erythromycin, in particular, is antibiotic resistance. The bacterium that causes acne has become used to the medication, so it no longer works against it. Benzamycin is an acne treatment medication that combines topical erythromycin with benzoyl peroxide. 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