Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine is a 400 mg hydroxychloroquine Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. Skin Discoloration; Vomiting; RARE side effects. We study how severe was Skin discoloration - bluish, when it was recovered, drug effectiveness, race, and more among people who take Plaquenil. This study is created by eHealthMe based on reports of 1,993 people who have side effects when taking Plaquenil from sources other than FDA, and is updated regularly. I was diagnosed almost 2yrs ago with Lupus, SLE & subacute subcutaneous. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil side effects skin discoloration Hydroxychloroquine and skin darkening Hi All. - LUPUS UK, Skin discoloration - bluish in Plaquenil how severe and when. Chloroquine bootsHow long do plaquenil side effects last Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions.. Plaquenil & skin discoloration -. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Anti-malarial drugs may be stromectol side effects in combination with prednisone to reduce the amount of steroid needed to control plaquenil and skin discoloration symptoms and thus to alleviate some of the side effects of the steroid. Skin discoloration is a possible side effect of plaquenil. It can also cause discoloration of your fingernails. Usually it is not serious, but you should let your doctor know about it as soon as you can."