I also have been having unexplained swelling of my tongue, wrists, bottom of my feet and lip, spreading up in my cheek. Now my wife and i are very concerned and planning on going to see my doctor soon. I know it isn't allergies because I have kept a diary and there is no pattern as in your case I too would like some help in clarifying it. Plaquenil mosquito History of chloroquine resistance Hydroxychloroquine drug classification Usually not Chapped lips is often due to lip eczema dryness, irritation, cracking, peeling. Too much sun, wind, or water exposure; excessive washing; repeated lip licking; and allergies to lip balm or lipstick ingredients are common causes. Allergic reactions hives, etc. can chap lips. Swollen lips are caused by underlying inflammation or a buildup of fluid under the skin of your lips. Many things can cause swollen lips, from minor skin conditions to severe allergic reactions. Lip and eye periorbital swelling are the most common. Swelling of the tongue, pharynx, and larynx is particularly problematic. Fatalities can occur because of laryngeal edema, but pharyngeal edema and tongue swelling can be similarly disastrous if they are massive. I have tried to put all of this on food, detergent, allergies, etc.. Currently as I'm writing this am having the same symptoms you describe under my feet, it started about 4-5 months ago, were swelling of the lips, tongue and side of the mouth swells up, and most recently started to get the swelling under my feet with the same description you noted, also my hand and my wrist, all these caused an itching feeling and felt very warm to touch and is difficult to walk on. I ate a chocolate apricot cake, something I have never had. The same exact thing that you have described has happened to me and much more regularly recently. my wife and i thought it maybe caused due to an allergic reaction, i did go to en allergist and after various tests he indicated that i am not allergic to anything. My foot had this crazy itch (left foot) and then I was walking and it felt like the outside of my foot had like gum or something stuck to the bottom of it. I have been told it is stress, but I don't feel stressed. Plaquenil lip swelling Swollen feet and plaquenil Anti-Inflammatories., Swollen Lips Causes, Treatment, and More Plaquenil in ana pregnancyMaqular degeneration plaquenilComparable drug to plaquenilPlaquenil and eye exams Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Angioedema - nih.gov. Hydroxychloroquine Side Effects, Dosage, Uses, and More. It reveals itself as crusting of the lips usually symmetrical and as painful ulcerations of the gums, lips, cheeks, tongue. Swollen glands, fever, and genital lesions may also occur. You should contact a doctor as soon as you realize you are having this reaction, or go straight to the emergency room. Plaquenil and Lip swelling - from FDA reports Summary Lip swelling is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Benlysta, and have High blood pressure. I had my lips injected today with Juvederm and am wondering if appearance is due to swelling? A Yes it is completely normal to have swelling and bruising the first day. The swelling and bruising could last a week - 10 days!