The pricing of generic medications for uninsured patients is irrational and counter-intuitive. Because of this, the uninsured patient can pay far too much for a generic drug. One might expect that the price of a generic medication to be “low”, and to not vary much from pharmacy to pharmacy. What inspired me to write this post is hearing from several different patients that they had paid exorbitant prices for their generic meds. Consider lamotrigine, the generic name for Lamictal, which is increasingly admired for its ability to prevent depression in bipolar II patients. A typical initial prescription for lamotrigine would be for 60 25 mg pills. At the lamotrigine page, enter your zip code (so you can see the pharmacies closest to you), the dosage of lamotrigine you’re interested in, and the number of pills you’d like to buy 4. Without insurance, the estimated cash price would be (from the Goodrx website, accessed 5/16/15: https:// Go to the Goodrx website (It is unnecessary to sign in or register) 2. In the example above, I’d enter 90403 (my office zipcode), lamotrigine 25 mg, quantity 60. The cheapest price ($13.98) is from “membership warehouse, name cannot be shown” (presumably Costco). There is no need to battle traffic in the Costco parking lot, however, because of these prices (which require printing the free coupon from the Goodrx website): Ralph’s $13.98 Pharmaca $14.08 Walgreen’s $14.38 (a 90% savings over the cash price) Von’s $14.63 But note, even with the coupon CVS $79.39 Rite Aid $107.33 7. distance=6&filter-location=&coords=&label=lamotrigine&form=tablet&strength=25mg&quantity=60.0&qty-custom=&language=&store-chain= Walgreens $149 CVS $134 Rite Aid $127. If you prefer your small, neighborhood, independently owned pharmacy (as I do), Goodrx will allow you to print out a coupon which you can take to your pharmacy. A black box warning is a consumer warnings with a black border placed on labels calling out the product’s serious health risks—like the one that appears on tobacco packaging. It is the most severe type of warning by the Food and Drug Administration (FDA). Black Box warnings are not something to take lightly. For the FDA to warn about a drug means it’s pretty bad (the last stop before a recall notice)! I believe the black box warnings are a result of the many lawsuits that are being won by injured patients and demanding them to warn others. 8 common drugs in various categories: Patients who stop taking Pradaxa without continuing some anticoagulation protocol increase the risk of stroke. In older patients, there’s a significant trend toward internal bleeding. Its mechanism of action involves blocking “thrombin” which causes blood to clot. See more here: https:// Why a Black Box warning? Adderall is a stimulant, amphetamine drug used to treat ADHD, but is also frequently used recreationally by college students and others to lose weight, stay awake and study longer, recreationally to get Xanax is a benzodiazepine drug. It’s also used to manage phobic behaviors and specific conditions like social anxiety. Prescription rates in the last 18 years have risen only 67%, but the number of Xanax related deaths per year has multiplied sixfold. Ciprofloxacin is in a class of antibiotics called “fluoroquinolones” and includes Levaquin and Avalox used to treat bacterial infections of all different types like chronic bronchitis, infectious diarrhea, urinary tract infections (UTIs) and more. Why a Black Box warning? 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