Plaquenil ocular toxicity

Discussion in 'Pharmacy Northwest Canada' started by SergeyA, 14-Mar-2020.

  1. misha XenForo Moderator

    Plaquenil ocular toxicity


    Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention.

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    Plaquenil Toxicity Plaquenil hydroxychloroquine is a medicine commonly used to treat patients with systemic lupus erythematosus and rheumatoid arthritis. After prolonged use, it can sometimes damage the macula and cause central vision loss. More in Eye Health. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Plaquenil hydroxychloroquine is a medicine commonly used to treat patients with systemic lupus erythematosus and rheumatoid arthritis. After prolonged use, it can sometimes damage the macula and cause central vision loss.

    Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.

    Plaquenil ocular toxicity

    The Risk of Retinal Toxicity with Plaquenil - Sjogren's, Plaquenil Side Effects on Your Eyes and Vision

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  6. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs.

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    The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects.

     
  7. max21 User

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Chloroquine - FDA prescribing information, side effects and uses Mefloquine Dosage Guide with Precautions - Best Microdosing Schedule By Dr. James Fadiman - Best.
     
  8. dj-bebot New Member

    Senior Care Consultant Pharmacist and President of MZ Associates, Inc. What causes seizures? Antipsychotic medication and seizures a review. Antipsychotics and seizures Higher risk with atypicals? - ScienceDirect
     
  9. darkman_07 Guest

    In vitro action of chloroquine on nucleic acid and protein. Addition of chloroquine to the incubation mixture, at a concentration of 1 or 10 mM, resulted in a significant inhibition of the nucleic acids and protein synthesis. Therefore, this effect on retinal nucleic acid and protein synthesis may be important in the pathogenesis of retinal disease observed during chloroquine therapy.

    Antimalarial drug, Chloroquine, reportedly effective.
     
  10. Seolomon Moderator

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