I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. How much plaquenil can you take with imuran Plaquenil and eye twitching Can u still have a flare while on plaquenil I have read about people stopping P & flaring up. Those who stopped it abruptly had real problems similar to what you are experiencing. If you really need to get off it, I would taper down slowly, very slowly. There is a similar posting on Healthunlocked, "Why oh why did u stop taking plaquenil." You may want to check it out. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Many doctors disagree about the effects of plaquenil on the arthritis. It does help in about 60 % of the cases of arthritis by significantly reducing the pain. However, about 20 – 30 percent of people stop using it because of the side effects. Side effects include digestive problems, skin rash and disorders of skin pigmentation. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. What are the side effects of stopping plaquenil Let me tell you what weaning down from Plaquenil is like., Long-Term Side Effects of Plaquenil for Rheumatoid. Aralen injectionAdverse effects of hydroxychloroquine sulfate Check with your doctor immediately if any of the following side effects occur Incidence not known. Blistering, peeling, loosening of the skin blurred vision or other vision changes chest discomfort, pain, or tightness cough or hoarseness dark urine decreased urination defective color vision diarrhea difficulty breathing Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Side effects of Plaquenil Other Drugs discussions.. Will you have Withdrawal syndrome with Plaquenil - eHealthMe. Has anyone had any side effects from STOPPING plaquenil? Also - does anyone have any great ways to prevent virus and illness, when weak? I seem to get cold after cold after cold this year. I had a diagnosis of seronegative RA in 2017. After two years of plaquenil, my disease is in remission and we have me reduced now to only 100mg per day. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. I started taking Plaquenil, and I'm supposed to be taking two 200mg pills a day, but I'm only taking one for a week to ease into it. So far I've woken up every morning very nauseous and with a lot of stomach pain and fatigue early in the day plus diarhea. I heard the side effects go away after a.