Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil cause itching Hydroxychloroquine porphyria cutanea tarda moa I started plaquenil 1.5 weeks ago, on the day my period started, so I haven't been on it for that long. I was just noticing, however, that I am NOT experiencing the intense ovulation cramps that have been plaguing me for a while I feel a teensie amt of discomfort, instead. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. I asked her for plaquenil since it's a non steroid anti inflammatory. She seemed hesitant to prescribe it. She told me that it could make me feel better or much much worse. She said after 3 days of burbur detox I could try 1/2 tablet of plaquenil every other day, but if i start feeling worse to stop immediately. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine makes me feel worse User Reviews for Hydroxychloroquine -, Hydroxychloroquine Reviews Everyday Health Plaquenil long term use side effectsWhat happens when you take plaquenil with out having lupus Went like this back and forth and it was definitely the medicine. Also I started to feel worse while taking it. It could be that the weather is getting colder and that always makes me feel worse. but we decided I couldn't tolerate an increase in dosage which was what would have been next on the treatment plan so we moved on to something else. User Reviews for Hydroxychloroquine to treat. -. Plaquenil for treatment - Lyme Disease - MedHelp. Is extreme fatigue a side effect of Plaquenil?. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. This medication may make these conditions worse. Call 911 if your symptoms feel life-threatening.