“Presumptive treatment” without the benefit of laboratory confirmation should be reserved for extreme circumstances (strong clinical suspicion or severe disease in a setting where prompt laboratory diagnosis is not available). Once the diagnosis of malaria has been made, appropriate antimalarial treatment must be initiated immediately. Chloroquine resistant falciparum malaria drugs Affect of hydroxychloroquine The treatment regimens for chloroquine-resistant P. vivax infections are quinine sulfate plus doxycycline or tetracycline, or, atovaquone-proguanil, or artemether-lumefantrine, or mefloquine. These treatment options are equally recommended. Chloroquine and mefloquine are options for use in infants and children of all ages and weights, depending on the presence of drug resistance at their destination. Primaquine can be used for children who are not G6PD-deficient traveling to areas with principally P. vivax. Doxycycline may be used for children who are at least 8 years of age. The combination is considered to be more effective in treating malaria caused by Plasmodium falciparum than that caused by P. vivax, for which chloroquine is considered more effective, though in the absence of a species-specific diagnosis, the sulfadoxine-pyrimethamine combination may be indicated. The clinical status of the patient: Patients diagnosed with malaria are generally categorized as having either uncomplicated or severe malaria. Treatment should be guided by three main factors: infections, the urgent initiation of appropriate therapy is especially critical. Chloroquine fansidar and mefloquine Mefloquine Dosage Guide with Precautions -, Malaria Prevention – Which is better for ra plaquenil or methotrexateHow to treat nausea from plaquenil Fansimef and Lariam were given with loading and maintenance doses, Fansidar and chloroquine as one tablet per week for 24 weeks. Of 567 enrolled subjects, 114 20% had parasitaemia on entry. Eight episodes of symptomatic falciparum malaria occurred during the trial, seven in the placebo group, and one in the Fansimef group. Mefloquine-sulphadoxine-pyrimethamine Fansimef, Roche in.. Sulfadoxine/pyrimethamine - Wikipedia. Sequential Treatment With Quinine And Mefloquine Or.. Sep 23, 2019 Mefloquine is a prescription medicine used to prevent and treat malaria. Malaria can be a life-threatening infection. Mefloquine does not work for all types of malaria. It is not known if Mefloquine is safe and effective in children under 6 months old for the treatment of malaria. Mefloquine resistance was first observed in late 1980s near the ThaiCambodian border It is frequent in some parts of Southeast Asia and has been reported in the Amazon region of South America and sporadically in Africa Resistance in P. falciparum to mefloquine in India was Mefloquine is now a widely used prophylaxis for chloroquine-resistant falciparum malaria. We emphasise the importance of careful reporting of side-effects if further deaths are to be prevented, as previously experienced with Fansidar.