Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine fish food Plaquenil throat pain Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Therefore, hydroxychloroquine may be used as a life-long therapy for patients with systemic lupus who are at an increased risk of cardiovascular disease. Other effects of hydroxychloroquine include A 15–20% decrease in serum cholesterol, triglyceride, and low-density lipoprotein levels Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine long term Hydroxychloroquine Side Effects Common, Severe, Long Term., Plaquenil Side Effects Common, Severe, Long Term - Plaquenil erectile dysfunctionChloroquine brain tumorChloroquine phosphate suspensionChloroquine toxicity of retinaChloroquine tablet price Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Hydroxychloroquine DermNet NZ. Hydroxychloroquine Plaquenil. BACKGROUND Hydroxychloroquine is used for the treatment of rheumatoid arthritis RA and systemic lupus erythematosus SLE. Long term studies have shown a high rate of termination of hydroxychloroquine treatment in patients with RA. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. The absorption half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. The long half-life can be attributed to extensive tissue uptake rather than through decreased excretion. Peak plasma levels of hydroxychloroquine were seen in about 3 to 4 hours.